Mandon is noted for his botanical work during the mid-nineteenth century while he was the director of a mine in Tipuani, Bolivia from 1848 to 1861.
Much of this collection is now housed in the herbarium of the Grand National Museum of Natural History in Paris.
He also collected plant specimens in the Canary Islands, Portugal, and Tunisia.
[1][2] Mandon edited four exsiccata-like series, one of them with the title Algae Maderenses.
[3] He initially trained to be a theologian and while in Paris worked as a tutor and secretary.