Gilles II married Adrienne de Goudeval (or Gondeval), Viscountess of Grimbergen, and had around five children.
[2] His father brought him to the court of Philip the Handsome, Duke of Burgundy, where he was appointed receiver for Luxembourg, Arlon, and Thionville on 20 March 1490.
He resigned in 1498 in favor of his brother Valérien de Busleyden and became the first master of the Chamber of Accounts in Brabant, rising to president by 1510.
[4] Giles held the title of Viscount of Grimbergen and was the Lord of Guirsch, Horst, Sint-Pieters-Rode, Kortrijk, and Thommen.
[6] Gilles II de Busleyden died on 14 July 1536 in Arlon, Habsburg Netherlands (now Belgium).