His company later merged with Spectrum Holobyte where he was CEO until its acquisition by Hasbro, after which he became Chief Creative Officer and General Manager of its Games.com group.

He has been on a number of boards of directors, including Wizards of the Coast, Niantic, Total Entertainment Network, FASA Interactive, Wickr, Aerospike, the Chinese American International School, Markle Foundation, Digital Promise, and Maxar Technologies.

Known investments of Alsop Louie Partners include Niantic, Inc., Wickr, Cleversafe, Ribbit, Zephyr Technologies, Gridspeak, Netwitness, and LookingGlass Cyber Solutions.

Louie has been on a number of boards of directors, including Wizards of the Coast, Total Entertainment Network, Direct Language, FASA Interactive, Netwitness, Motive Medical, Wickr, Gridspeak, the National Venture Capital Association (NVCA),[3] Zephyr Technologies, the CIA Officers Memorial Foundation, Aerospike, GreatSchools and the Chinese American International School in San Francisco.

[2] Louie was appointed to the United States National Security Commission on Artificial Intelligence (NSCAI) that was established in 2018 and issued its final report in March 2021.

[12][13] In 2009, representing his company Alsop Louie Partners, he sat as a member of the committee for The Symposium on Avoiding Technology Surprise for Tomorrow's Warfighter working alongside Raytheon.