Transitioning from the ring to the screen, Carano landed her first major role as the lead of the action film Haywire (2011), which was followed by appearances in Fast & Furious 6 (2013) and Deadpool (2016).

[9] Carano graduated from Trinity Christian High School in Las Vegas where she led the girls' basketball team to a state title.

[16] Carano proved critics wrong when she defeated Maxwell for the second time; the first victory coming in a Muay Thai bout.

She fought on the February 10, 2007 Showtime EliteXC card, defeating Julie Kedzie via unanimous decision in what was called the "Fight of the Night".

The Fight Network and other news outlets reported that Carano was rushed to the hospital by ambulance for dehydration while attending a World Extreme Cagefighting event as a spectator.

[18] Carano fought on the September 15, 2007 Showtime EliteXC card, where she defeated Tonya Evinger via rear-naked choke for her first career win by submission.

Carano worked her opportunities by hitting Kobold at every turn whenever the fighters separated while opening a huge gash on the inside of her opponent's eyebrow in the first round.

[32] Carano lost the fight against Cyborg by TKO at 4:59 in the first round, giving her first-ever loss in her professional MMA career.

[40] During her appearance on the Joe Rogan Experience 690 podcast, Ronda Rousey said a fight between Gina Carano and her had been planned for December 2014, but never materialized.

[44] Based on true events, it is about five American women from Las Vegas who attempt to fight the best Muay Thai fighters in the world.

[45] Along with Lisa King, Carano served as a mentor to aspiring fighters in the 2007 Oxygen reality series Fight Girls.

[citation needed] She appeared in Command & Conquer: Red Alert 3 as Natasha,[46] portraying the Soviet sniper/commando in various cut scenes.

[48][49][50] Christy Lemire of the Associated Press stated: "[Carano's] dialogue delivery may seem a bit stiff—and she has acknowledged that Soderbergh made some tweaks to her voice in post-production—but she has tremendous presence: an intriguing mix of muscular power and eye-catching femininity.

Carano appeared in Fast & Furious 6 (2013) as a member of Special Agent Luke Hobbs' (Dwayne Johnson) Diplomatic Security Service team.

"[58] In July 2013, she and comic book creator Rob Liefeld announced they were working on a big-screen adaptation of Liefied's Avengelyne in which Carano would star as the titular character.

[59] Carano appeared in the 2013–2014 Fox series Almost Human episode "Unbound", where she played the part of an XRN combat android named Danica.

[64] In February 2021, Carano shared an Instagram post that compared "hating someone for their political views" to the persecution of Jews by their fellow citizens during the Holocaust[65][66][67] and included an image taken during the Lviv pogroms.

[71] Shortly afterward, Lucasfilm stated that Carano was no longer employed by the company, saying that "her social media posts denigrating people based on their cultural and religious identities are abhorrent and unacceptable".

[64][73] A week later, Carano announced she would be developing, producing, and starring in a new film project with conservative media company The Daily Wire.

[77][78] By fall 2021, the White Knuckle project had been cancelled at Carano's behest, due to her unwillingness to comply with Hollywood's COVID-19 mask and vaccine requirements.

She stated, "After we announced our first project this summer, the Hollywood unions started debating vaccine mandates for cast and crew, and I wasn't into that.

Daily Wire co-founder and co-CEO Jeremy Boreing recalled Carano's demand to "find a different movie", and her statement, "To hell with it, I'll quit my union.

The group began production on the replacement film, a Western entitled Terror on the Prairie, that was released exclusively to Daily Wire subscribers in June 2022.

[80] In February 2022, Carano explained her social media posts, saying that she "shared a meme, I translated into: Don't let the government pit you against each other or history tells us that could go wrong.

[90] Gina Carano v. The Walt Disney Company, Lucasfilm LTD. LLC, and Huckleberry Industries (U.S.) Inc. is set to begin on September 25, 2025.