Immediately after graduation, she served as Vice President and Comptroller of Sampaguita Pictures, VP Enterprises and Jose Vera Corporation.

On February 15, 1997, de Venecia also signed a Memorandum of Agreement with then DILG Secretary Robert Barbers that prepared the setting-up of Women’s and Children’s Desk in every police station in the country.

[citation needed] On December 16, 2004, de Venecia established the INA (Inang Naulila sa Anak) Foundation.

[citation needed] In 2007, she started her third project as President of the CSFI, The Haven for the Elderly, a 20 building facility for senior citizens in Tanay, Rizal.

From its original 9 buildings, it has expanded as a 16-building facility with 2 livelihood centers, an inter-faith chapel, a gym, an administration office, several residential cottages, an air-conditioned nursery and a sick bay with dental and medical clinics.

[citation needed] She initially filed her bid for reelection ahead of the 2016 elections but later withdrew on December 8, 2015 and supported the candidacy of her son, Christopher, who eventually succeeded her.