Before World War II began, and the Japanese occupied the Philippines, several Sampaguita films enjoyed box office success in the region.

After the war ended and the Philippines was granted its independence by the United States, Sampaguita made several war pictures in 1946, including Guerilyera, with Carmen and newcomer Celso Baltazar, Maynila, the comeback picture of Corazon Noble featuring Tita Duran, and Isumpa mo Giliw, with husband-and-wife team Angel Esmeralda and Corazon Noble.

After several war musicals became popular, the studio created a new star team with real husband and wife Pancho Magalona and Tita Duran.

[6] In the early fifties several actors appeared in the studio's productions, including Alicia Vergel and her husband César Ramírez in Ukkala, Diwani, the Philippine folk hero Bernardo Carpio, MN and many more.

The infamous tandem of husband-and-wife Lolita Rodriguez and Eddie Arenas made some dramas together, like Kundiman ng Puso, Busabos, Cicatriz and Mapait na Lihim.

Susan Roces took her first lead role as a boxer in Sabungera opposite Luis Gonzales, but the film was not a box office hit.

[7] In 1996, the company ventured into television with GMA Network; they produced the drama anthology series Pira-pirasong Pangarap which lasted until 2003, which started another co-production Nagmamahal, Manay Gina.