He began his career in Palermo as well, conducting the local premieres of Tristan und Isolde in 1909, and Parsifal in 1914.

He then appeared in Rome and Milan, where he conducted several local premieres (mostly Wagner operas) and many revivals of rarely performed operas such as Lucrezia Borgia, La straniera, Beatrice di Tenda and L'incoronazione di Poppea.

This included the Western Hemisphere premieres of Puccini's La Rondine (first version) in 1917 and Turandot in June 1926 with Muzio and Lauri Volpi, two months after the world premiere at La Scala.

He left a noted recording of La forza del destino from 1941, with Maria Caniglia, Galliano Masini, Carlo Tagliabue, Ebe Stignani, Tancredi Pasero, and Saturno Meletti.

His son Gino Marinuzzi Jr (7 April 1920, New York City – 8 November 1996, Rome, Italy) was also a conductor and composer of music for films.