He was well known for his breakthrough hit "Questo vecchio pazzo mondo" ("This old crazy world"), a cover of P. F. Sloan's "Eve of Destruction", and for the song "Ma che freddo stasera (Such a Cold Night Tonight)" that he sang in the movie Yuppi du (1975).

Celentano used the same music tracks and lyrics in 1984 on his album I miei americani (My American), a collection of U.S. hits translated into Italian, and again in the first episode of his 1999 television show, Francamente me ne infischio (Frankly I don't care) in 1999.

He is credited with the soundtracks of Segni particolari: bellissimo (1983) and Joan Lui - Ma un giorno nel paese arrivo io di lunedì (1985).

In addition he did numerous work on the music of Celentano's films; a highlight being his hit "Ma che freddo stasera (Such a Cold Night Tonight)" (which Santercole sang in English), from the movie Yuppi du (1975).

One day he visited Celentano, who had landed a role in the movie, on set; the director, Paolo Germi, saw him, thought he had a good face, and cast him as the Sergeant.

[3] As an actor, Santercole has worked with directors such as Pietro Germi, Dino Risi, Giuliano Montaldo, Luigi Comencini, Luciano Salce, and Mario Monicelli.

On 22 January 2007 Santercole agreed to participate with Varese at a celebration of the 50th anniversary of rock 'n' roll in Italy, along with Pennant, the Rebels, Rosie, Ghigo Agosti, and others.

2009 in June he hosted the programme of Rai Two Stracult Show of Marco Giusti German in a sketch comedian with Stefano Sarcinelli and Nicola Vicidomini.

On 13 April 2010 Santercole released a new album, titled Nessuno è solo, on which he had composed all of the music (Mimmo Politanò wrote the lyrics).