[2] Whigham had her first break in the acting world starring alongside Ellery Sprayberry in the 2016 short film Pinky.
[3] Following her acting debut, she won roles on a variety of TV shows including Shameless, Son of Zorn, 13 Reasons Why, and The Orville.
[7] On February 26, 2018, it was announced that Whigham would appear in the second season of Netflix's The Punisher.
[8] In 2019, she co-starred in the film Saving Zoë, which was an adaptation to Alyson Noël’s bestselling young adult novel of the same title, starring alongside sisters Laura Marano and Vanessa Marano.
In 2022, she was cast as Blaire Bennett on the Peacock series Ted, the television prequel of the film of the same name.