He was the Bishop of the Eparchy of Piana degli Albanesi, a diocese of the Italo-Albanian Catholic Church in Sicily, Italy from 2015 to 2020, where he remained Apostolic Administrator until 19 June 2023.

He was also active in the Ukrainian Eparchy of Stamford, Connecticut, and in the Ruthenian Archeparchy of Pittsburgh, Pennsylvania.

He continued to hold several other positions, including sincello for canonical affairs and judicial vicar in the Archeparchy of Pittsburgh, professor of canon law and ecumenical theology at the Byzantine Catholic Seminary of Saints Cyril and Methodius of Pittsburgh, and judge of appeal for the Philadelphia Archeparchy of the Ukrainians.

[1] On 31 March 2015 he was named by Pope Francis to the bishopric of the Eparchy of Piana degli Albanesi.

On 25 February 2020, Pope Francis appointed him secretary of the Congregation for the Oriental Churches and gave him the personal title of archbishop.