He subsequently joined Inter Milan in 1951, making his Serie A debut that season in a 3–1 home win over Legnano on 21 October.

He remained at the club for 7 years, playing a total of 191 matches with the team across all competitions (Serie A, European Cup and Coppa Italia).

He made his debut on 11 April 1954, in a 3–1 away win over France, and was a starting member of the Italy team that took part at the 1954 FIFA World Cup, despite competition from several other excellent Italian goalkeepers at the time, such as Leonardo Costagliola, Giovanni Viola, Giuliano Sarti, and William Negri.

[1][2][4][5][7] An aggressive, courageous and spectacular goalkeeper, Ghezzi was known in particular for his athleticism, agility, reflexes and acrobatic saves, as well as his speed when rushing off his line to anticipate or challenge opposing strikers; his playing style as a sweeper keeper inspired his nickname kamikaze.

Despite his shot-stopping abilities and reputation as one of the greatest Italian goalkeepers of his generation, he was also at times criticised for his mentality and consistency, and was known for letting his emotions get the better of him on occasion.