Giovanni Andrea Lampugnani (died 26 December 1476) was a member of the Milanese nobility and an assassin of Galeazzo Maria Sforza, the Duke of Milan.
Although the family appealed to the Duke, there was no government intervention on the matter, resulting in utter contempt on the part of Giovanni.
The Duke, although popular as a patron of the arts, was known to be rather ruthless in his rule and something of a womaniser, traits which encouraged more enemies to emerge amongst the government ranks.
Two other officials, Carlo Visconti and Gerolamo Olgiati soon joined Giovanni in a conspiracy to assassinate the Duke.
In the days immediately following the Duke's assassination, other Lampugnani family members were arrested on suspicion of compliance and much of their property destroyed by mobs.