He was born in Rossano, Calabria, but moved to Rome as a young man.
Palatino's Libro nuovo d'imparare a scrivere is the best-known Renaissance treatise on calligraphy.
He dedicated it to the Academia dello sdegno (Academy of the Disdainful), of which he was secretary.
[1] As a calligrapher, Palatino was fascinated by ciphers and generally by the metamorphosis of the alphabet.
[2] The serif typeface designed by Hermann Zapf and released in 1948 was named after Giambattista Palatino.