Giovanni Battista Savelli (1422 - 18 September 1498, Castel Gandolfo) was an Italian Roman Catholic cardinal.
He was born into the aristocratic Savelli family, which had produced two popes: Honorius III (1216–1227) and Honorius IV (1285–1287) and numerous cardinals carrying this surname: Bertrando, Silvio, Giulio, Fabrizio, Paolo and Domenico Savelli.
He was created cardinal deacon by Pope Sixtus IV in the consistory of 15 May 1480 and received the deaconry of Santi Vito e Modesto, Rome.
He was appointed legate to Genoa to help negotiate a reconciliation between the feuding Fregoso and the Adorno families, and to supervise the arming of the papal fleet against the Ottoman Empire.
He developed a dispute with the Orsini Pope Sixtus IV, which led to being accused of treasonous correspondence with Alfonso of Naples, and imprisoned for 18 months in Castel Sant'Angelo together with Cardinal Giovanni Colonna.