Around 1425 he was siniscalco (prime minister) of Naples, count of Avellino, lord of Capua, Melfi, Venosa and numerous other fiefs in Campania and Apulia.
However, as the Aragonese soldiers had failed to capture Joan in the siege of Castel Capuano, Sergianni was freed and fled to Aversa with the queen.
The situation cleared when Alfonso was called back to Spain, and the queen returned to Naples together with Louis, to whom she was then betrothed.
On 19 August 1432, Sergianni Caracciolo was stabbed by four knights in the service of the queen in his room in Castel Capuano.
His elaborate sculpted tomb is located in the church of San Giovanni a Carbonara in Naples.