The excellent game at the youth teams may participate Drenthe several times with the main force.
On January 6, 2008 Drenthe makes his appearance by scoring 8 goals in one match at the highest level in the derby against SV Robinhood (3-4 loss).
In September 2007, Drenthe and his compatriots Kromorejo Ruiz and Fabian van Dijk moved to the Netherlands to a three-week internship with the youth of SC Heerenveen.
Drenthe played in exhibition games for Heerenveen in spite of level A1 and knew a good impression during his internship.
Drenthe was recalled by coach Kenneth Jaliens for the 2014 FIFA World Cup qualifiers.