[5] Orsini was appointed bishop on 14 January 1353 by Pope Innocent VI while only in minor orders.
[4][5] He was the last in a string of largely absentee bishops, succeeding Ildebrandino Conti.
[6] At Avignon, he was a notary, while also being an archpriest of Saint Peter's Basilica in the Vatican.
[3] He appointed vicars general to govern his diocese in his absence, each usually serving for about one year.
[7] His first vicar was Nicolò Matafari, his brother's chaplain and the archbishop of Zadar.