The series contains a collection of short stories about romantic relationships of high school girls.

Written by Masaya Hokazono [ja] and illustrated by Betten Court [ja], Girl Friend started with a series of one-shot chapters published in Young Jump Zōkan Mankaku and Weekly Young Jump from May 1 to November 27, 2003.

[2][3] The series started an irregular serialization in the latter on February 12, 2004;[4] another chapter was published in Young Jump Zōkan Mankaku on March 16 of that same year.

[9][10] BD Gest' claimed that the series can be summarized in three words: "School, sex, and socks".

[14] Animeland commended the manga for "every possible relationship combinations between young adults" without pudeur.