Girls' High School is a defunct secondary school that was located at various times in the Downtown Boston, South End and Roxbury sections of Boston, Massachusetts.

It was initially located above a public library in the former Adams schoolhouse on Mason Street.

[3] In 1869, construction began for a purpose-built school building, located on Newton Street between Tremont and Shawmut Avenue.

That building was designed for just under 1000 students, with 8 classrooms, 15 recitation rooms, 3 studios, chemical, physical, and botanical laboratories, and a hall, as well as facilities dedicated to the Girls' Latin School.

By 1903, the high school's share of this space was described as insufficient in the Boston Globe.