Three teenage girls — Ellie (Hallinan), Magda (Abrahams) and Nadine (Kwolek) — are best friends that go through the somewhat weird and wonderful world of boys together.

The show is narrated by Ellie, and normally portrays her life events in her sketchbook, which blends the show's live action with animation in a similar manner to the US teen sitcom Lizzie McGuire.

She lives with her father and his girlfriend (later wife) Anna, and her youngest half-brother Benedict "Eggs".

Girls in Love was repeated for the first time since 2005 on CITV's digital channel from September 2010.

The DVD releases are episodes strung into movies with music changes, due to copyright reasons.