Being designed for the church, he was sent at the age of twenty to the University of Padua, where, under the guidance of Guido Panciroli,[2] he applied himself with great ardour to the study of belles-lettres, jurisprudence, philosophy and theology.

At the age of twenty six he published his Commentary upon the Institutes of Gaius, which was well received, and the public professorship of jurisprudence was offered to him by several universities.

He joined the Accademia degli Umoristi, just then instituted at Rome, and embracing all the most learned men in that city, and became one of its most active members; his academical name was Aggirato.

Up to this period Aleandro, whose constitution was naturally delicate, had accustomed himself to great regularity and simplicity of life; but in France the necessity to which he was subjected of living more freely, threw him into an ill state of health, which compelled him, instead of accompanying the cardinal, who proceeded into Spain, to return to Rome, where he died on the ninth of March 1629.

Aleandro's main works are: He also left in manuscript Commentarius in Legem de Servitutibus, various treatises on antiquarian subjects, poems in Latin and Italian, a particular account of which is given by Mazzucchelli.