Learning the basics of art under his father's watchful supervision and trained in the traditional Sienese style of painting (he was a contemporary of Giacomo Pacchiarotti, Bernardino Fungai and Pinturicchio), he worked on several frescoes and altarpieces undertaken by his father's studio.
His first independent work, The Assumption of Mary of 1498 for the city of Montalcino (whose museum still holds it), Girolamo shows several differences to his father's style, with more elongated figures with more pronounced expressions.
It echoes two female portraits painted by him at about the same time (one in the National Gallery of Art, Washington).
Surviving documents and works show he mainly produced religious works, but also created paintings on secular themes for domestic settings and cassoni - the latter include his Judgement of Paris tondo (intended for a bedroom and now in the Louvre).
The Gallery paid an undisclosed amount for this painting which was said to be in the tens of millions of dollars.