[1] After studying at the University of Bologna, he moved to Rome and entered ecclesiastical life under the tutelage of his uncle Cardinal Uberto Gambara.
[1] He received the red hat and the titular church of San Giovanni a Porta Latina on 3 June 1561.
[1] He participated in the papal conclave of 1565-66 that elected Pope Pius V.[1] On 14 May 1568 he opted for the titular church of San Martino ai Monti.
[1] On 22 January 1570 he was consecrated as a bishop in the Sistine Chapel by Cardinal Otto Truchsess von Waldburg, Prince-Bishop of Augsburg, assisted by Antonio Helius, titular patriarch of Jerusalem, and Marcantonio Maffei, Archbishop of Chieti.
[1] In 1572, he was extraordinary legate responsible for fortifying Ancona against the maritime threat from the Ottoman Empire.