San Silvestro al Quirinale (or St. Sylvester on Quirinal Hill) is a historic church in central Rome, Italy.

[citation needed] In 1507, the church was granted to the Dominicans of the Florentine Congregation of St Mark by Pope Julius II.

[citation needed] In the period when conclaves to elect a new Pope were held at the Quirinal Palace, the inaugural procession of the Cardinals started from this church.

On the walls are the Circumcision of Christ and Adoration of the Magi by Jacopo Zucchi and The Dream of St Joseph and The Slaughter of the Innocents by Raffaellino da Reggio.

The first chapel on the left side has a fresco by Avanzino Nucci, Pope St Sylvester Baptizing Emperor Constantine.

The altarpiece in the second chapel on the left is by Giacinto Gimignani, and depicts Pope St Pius V and Cardinal Alessandrino in Adoration of the Virgin.