In 1688 he married the great heiress Giovanna van den Eynde, from whom he acquired a fortune, the title of Marquess of Castelnuovo, and the Palazzo Zevallos Stigliano.

[3][4] He was born on December 10, 1671, in Rome, the son of Filippo Colonna, Lord of Sonnino, and his wife Clelia Cesarini.

As a teenager, he was married to the great heiress Giovanna van den Eynde.

Through his marriage to her, he acquired the title of Marquess of Castelnuovo, the Palazzo Zevallos Stigliano, a huge art collection, and the greater part of the van den Eynde's fortune, all of which contributed to boost his position.

[1] King Philip V of Spain, sovereign of the kingdom of Naples, granted him the Grandeza de España in 1715.