On 19 January 1626 he was elevated to cardinal by Pope Urban VIII and installed as Cardinal-Priest at Santa Francesca Romana in 1627.
In 1635 Ginetti was appointed Papal Legate to Austria in an attempt, by the Barberini, to put him forward as an elder statesman.
Ginetti returned to Rome where in 1639, he and Cardinal Bernardino Spada gave assistance and protection to a visiting Carlo Cesare Malvasia.
[2] Unimpressed by Ginetti's efforts in Austria, Pope Urban VIII sent him to Ferrara as legate in 1640 where he amassed considerable wealth and remained until 1643.
Contemporary, John Bargrave, suggested Ginetti considered himself papable; suitable for election to the papacy.