Bofondi was born on 24 October 1795 in Forlì, the son of the former president of the municipality and grandson of Lorenzo Romagnoli, who was the governor of the prefecture.

He decided to enter the ecclesiastical field and studied in Bologna, where he graduated utroque iure 1817, then began practicing at the Roman Curia.

He discussed plans of "cautious reforms" with the help of moderates and the advice of Giuseppe Pasolini, which briefly put a stop to the demonstrations.

Two days later, a commission was created to help draft a constitution, to clarify the powers and limits of the Papal ministry, with Bofondi serving on it with several others.

[1] As protests continued, he thought to reorganize the army "by calling officers from outside the State to command positions"; however, shortly afterwards revolution broke out in Paris and under the pressure of the riots, Bofondi resigned effective 10 March 1848, being replaced by Giacomo Antonelli.