[1] In 1993 he moved to the editorial team of Studio Aperto (at the time directed by Vittorio Corona and then by Paolo Liguori), where he hosted all the editions of the news program.
In 2000 (under the direction of Paolo Liguori and then by Mario Giordano), he became the editor-in-chief of the Rome editorial team of Studio Aperto, a position he held until 2001.
[5] At the same time as these commitments, in the 2013-2014 television season (from September to June), he hosted Dentro la notizia (an in-depth programme in the late evening produced by TG4) on Rete 4;[6] in autumn 2014 he returned to host the new edition of Dentro la notizia, but the director of TG4 Mario Giordano had to cancel this second edition of the news programme because the ratings had fallen below the average ratings of Rete 4 and so Brindisi remained at TG4 as host of the evening edition and editor-in-chief.
[7][8] Since April 7, 2021, he has hosted a new news and current affairs program broadcast in prime time on Rete 4, entitled Zona bianca.
On November 6, 2024, he hosted the afternoon special on Rete 4 The President, a spin-off of Zona bianca dedicated to the presidential elections in the United States.