[9] De Giacomo's research interests concern theoretical, methodological, and applicative aspects of different areas of Artificial Intelligence and Computer Science.
[10] He is internationally renowned for his significant contributions to the field of knowledge representation and reasoning, situation calculus, generalized forms of automated planning, temporal logics, verification and synthesis of KR-based systems, and business process modeling.
[16] In 2019, De Giacomo was awarded an ERC Advanced Grant for the project titled White-Box Self-Programming Mechanisms (WhiteMech) (2019-2024).
[17][18] In 2016, De Giacomo was elected an AAAI Fellow "for significant contributions to the field of knowledge representation and reasoning, and applications to data integration, ontologies, planning, and process synthesis and verification".
[20][21] De Giacomo is the co-founder and scientific advisor of OBDA systems,[22] an innovation startup of Sapienza University of Rome, and a company of the Almawave Group.