[2] Nobili attained his doctor's degree in natural science from the University of Turin in 1899 when he was also appointed as an assistant in the university's Museum of Zoology.
Later, in 1903 he was appointed as an assistant in the University of Turin's Museum of Comparative Anatomy.
While he was a student Nobile had published some notes on botanical subjects but soon turned his full attention to zoology.
This series of papers were an important contribution to the science of carcinology and contained descriptions of many new genera and species, as well as critical discussion of taxa which had already been described by others.
[2] His most notable work was his monograph on the stomatopods and decapods of the Red Sea.