Spataro was born in Vasto, Italy to Anna and Alfonso Nasci, who were a high-class Italian family, in the urban center within the province Chieti.

After studying in his birth city of Vasto, Spataro transferred to a boarding school called Montecassino in 1908, the adjustment to this new life made easier by the death of his father in 1910.

During the First World War, Spataro initially served as a "corpo specializzato del Genio" and was later promoted as an official.

Eventually, Spataro’s close relations with Luigi Sturzo- led to his membership to the Roman sector of the Italian People's Party in 1919.

He held this post, until 1950, when he stepped down as president of RAI, in order to assume the minister of communications role.