At the age of twenty years, was chosen to become an assistant professor for design at the Scuola Tecnica per gli operai in Palermo.
Returning to Palermo, he worked in lithography for many years, and illustrated the Journal of Natural Sciences for the account of the scientists Gaetano Giorgio Gemmellaro and Giuseppe Inzenga.
He made reproductions of Sicilian artworks, using etching and lithography and chromolithography.
Tambuscio also illustrated the work of the Monsignor Gioacchino Di Marzo titled I Gagini e la scultura in Sicilia nei secoli XIV e XVI.
He became titular professor of painting and watercolor at the Royal School of the Museo Artistico-Industriale of Palermo.