It was released digitally on May 18, 2012, as the lead single from his fourth studio album The Bad & the Better,[2] before it was serviced to contemporary hit radio on October 23, 2012.

[3] The song was featured in the 2013 animated film Escape from Planet Earth and the trailer for The Smurfs 2.

[8] A lyrics video premiered on May 22, featuring a girl translating the song into sign language.

[13] "Give Me Your Hand (Best Song Ever)" peaked at number 30 on the US Mainstream Top 40, remaining on the chart for twelve weeks.

[13] The song was used in Smithfield-Selma High School's lipdub video for the FOX 50's 2013 Lip Dub Project competition.