Prior to the 2005 general election, boundary changes led to a new constituency named Glasgow Central being introduced.

[2] Prior to its abolition, the seat was held by Alison Thewliss of the Scottish National Party (SNP).

2005–2024: Under the Fifth Review of UK Parliament constituencies which came into effect for the 2005 general election, the boundaries were defined in accordance with the ward structure in place on 30 November 2004 as containing the Glasgow City Council wards of Anderston, Bridgeton/Dalmarnock, Calton, Govanhill, Hutchesontown, Kelvingrove, Kingston, Merchant City, Pollokshields East, Strathbungo, and Toryglen.

The Central constituency sat across the River Clyde, and included the areas of Kelvingrove, Anderston, Merchant City, Calton, Bridgeton, Kingston, Gorbals, Govanhill and part of Pollokshields .

On abolition for the 2024 general election, the contents of the seat were distributed as follows:[7] This former constituency took in Glasgow city centre to the north, including Kelvingrove Art Gallery, the main railway stations, Glasgow Cathedral and the Scottish Exhibition and Conference Centre.

[8] Glasgow Central was estimated to have voted to Remain in the European Union by 66.6% in the 2016 referendum on the UK's membership of the EU.