Glen Osmond Road starts at the intersection with South Terrace along the southern border of the Adelaide city centre and heads southeast, intersecting with Hutt and Greenhill Roads through the Adelaide Park Lands, continues southeast through Eastwood and Frewville, before ending at the intersection with Cross Road, Portrush Road and South Eastern Freeway in Glen Osmond.

It is a community main street stationed in the leafy suburbs of Adelaide's south east.

The Glen Osmond Road Precinct Association (GORPA) is an association guiding the growth and development of Glen Osmond Road and marketing the local business community.

GORPA is funded by an exclusive rate applied to properties on the City of Unley side of Glen Osmond Road.

Each council has staff dedicated for Business and Economic Development.