It starts off as Lucas Avenue at 7th Street west of Downtown Los Angeles, California.

The name changes at Beverly Boulevard in Echo Park, north of the Hollywood Freeway (U.S. Route 101) at Bellevue Avenue.

[citation needed] Northeast of Riverside Drive and Interstate 5, it merges with Hyperion Avenue, forming the Glendale-Hyperion Bridge over the Los Angeles River.

[citation needed] As it passes underneath the train tracks of the Metrolink and Amtrak, it enters Glendale and changes to Brand Boulevard, a principal north–south thoroughfare in Glendale, marking the west–east postal divider of that city that finally ends at Kenneth Road.

[2] An obelisk raised in 1954 by Frank McKee, a former actor, on what they believed was the former site of the Sennett film studio, to commemorate the film industry, used to be located on Glendale Boulevard but was removed in 2008.