She began her artistic career in 1975 with a series of ceramic artifacts and later, in the mid-80s onward, creating works on canvas and wooden panels.

[2] Collector Panza di Biumo has written: Gloria Graham's work is inspired to a spiritual research, that openly reveals itself in small-sized paintings.

[3]She also has done large works of a similar nature by drawing the molecular structure of things such as salt and quartz on walls.

In the mid-1980s she developed a technique of painting on wooden panels with a mixture of kaolin and hide glue, similar to the method used in the making of Tibetan tankas, which she then drew over with graphite.

[6] In her Famine Series, the flags of eight African countries were painted on used damask napkins, a comment on our relationship to the fed and to the hungry.