The film stars Marcel Musters as a mentally ill man, with Monic Hendrickx and Elsie de Brauw as his two sisters.

[3] By July 2018, the film had been shot and the actors playing the three main roles had been announced, but the date of the cinematic release was still not set.

[4] It was then confirmed that God Only Knows would premiere at the International Film Festival Rotterdam (IFFR) on 29 January 2019 and would receive a Dutch cinematic release on 4 April 2019.

The Cineuropa reviewer at IFFR praised de Jong for "approaching mental health issues and vulnerability with a certain amount of sensitivity, in a touching portrait of a condition that is rarely tackled on the big screen" and called her "a true auteur".

The reviewer remarked that the film raised an interesting question about the foundational role of the idea of suffering in Western European culture.