[1] Their earliest days include playing Nightingale's and The Wetlands Preserve in New York City where their contemporaries were The Spin Doctors, Blues Traveler, Jono Manson and the Dreyer Brothers.

GSW was an early adapter of internet marketing, acquiring a domain name and electronic mailing list ahead of many others in the scene.

Pifer had met Jon Bevo earlier at NYU and he jammed with them on keyboards, eventually joining when the band began to coalesce.

[5] Other bands that got their start at the legendary Lower East Side venue include Blues Traveler and the Spin Doctors.

In 1990 they recorded three nights at The 712 Club and eventually released “Live at the 712 Club.”[7] 1991 stands as a major turning point for God Street Wine.

God Street Wine financed Bag themselves with the help of friends and sold it at shows before making a distribution deal with Ripe 'n' Ready.

Despite the strain Faber insists there were benefits to working with Dickinson, “One of the best things Jim did was bring in a vocal coach named Sanchez Harley.

Pifer, Faber & Maxwell had no desire to curb their touring activities, so Bevo and Osander chose to step away from God Street Wine.

To put a close to this chapter the band announced a three-night run (December 21–23, 1999) at The Wetlands Preserve, the club that had served as home base during their upward trajectory.

Special guests sit-ins with GSW that night included John Popper of Blues Traveler and Oteil Burbridge of the Allman Brothers Band.

On July 8, 2008, Long Island's David Katz created the fan Facebook page "Bring Back God Street Wine".

In Katz's own words, “I was listening to some GSW in my office and thought, I miss these guys, I wish they would play again - I decided to search Facebook and see if there were any like-minded individuals - when I searched God Street Wine all I found were a few people who listed them on the section of music they liked - so, I decided to start a page and see if I could get some attention.” Soon after starting it, long time winos and eventually, members of the band themselves joined the group.

For the first time since they reunited when Wetlands Preserve was closing, they reformed in the afternoon of May 30 with their original lineup to play a tribute show in Ridgewood, NJ.

On March 5, 2010 God Street Wine announced an updated website and said, "We thought it wise to alert you to this change and more importantly we have some additional news we hope you find pleasing.

The organizers of Jam Cruise, which already had 8 successful excursions under its belt offered God Street Wine a spot on the 9th edition and they accepted.

Notably, on July 22, 2011 Bevo, Faber, Pifer, and Maxwell backed by Joe Russo on drums, and accompanied by Jason Crosby on fiddle, appeared at The Gathering of the Vibes in Bridgeport, CT.[25] In March 2012 God Street Wine announced via their website and social media that they would be returning to play in California for the first time in nearly 15 years.

A week later, back on the east coast, they played three sold out nights at Gramercy Theatre, a venue that has become their de facto home since reuniting in 2009.

In addition to serving as Lesh's band each night they also opened all three shows with sets of original God Street Wine music.

[29] The summer of 2013 found God Street Wine performing two nights in New York City at Brooklyn Bowl, their first shows at that venue.

The live version of $1.99 Romances recorded at TRI Studios in 2012 with special guest Bob Weir, and a two-disc collection of unreleased rarities and concert-staples, called Gots To Rewind make up the rest of the set.

God Street Wine ended their busiest year since reuniting with two celebratory nights (December 20 and 21) at the Gramercy Theatre In New York City.

As opposed to the average God Street Wine show that often includes a few covers, the band stuck to original material, save for a Christmas instrumental.

[34] In January 2016 God Street Wine played shows with Strangefolk and Assembly of Dust at the Capitol Theater in Port Chester, New York and the Paradise Rock Club in Boston, MA.

[39] In advance of their Summer 2018 Tour God Street Wine released two new studio recordings "Smile on us Sarah", and "On The Shores of Silver Lake".

[40] In early December 2018 God Street Wine released a video to their YouTube channel featuring a performance of the instrumental composition "Stupid Hat".

[43] Asbury Park, NJ, Richmond VA, Fairfield, Ct, and Hampton, NH are cities the band has not yet visited since reforming in 2009.

One June 4, 2019, God Street Wine announced a new album This Fine Town and made it immediately available via all major online music streaming and download services.

God Street Wine also announced that a limited edition, signed, physical copies of This Fine Town would also be for sale on their summer tour.

[47] In 2001 Lo Faber recorded and released the double album rock opera Henry’s House in upstate New York at his home Studio, The Great Northern.

After a short period playing with the band Poor Uncle Henry, he recorded and toured for a number of years with Damien Rice.