It follows Marc Spector, Steven Grant, and Layla El-Faouly as they help Khonshu defeat Ammit and her avatar Arthur Harrow.

Harrow, Ammit, and their followers begin judging everyone in Cairo, until Spector, Grant, El-Faouly, and Khonshu arrive to engage them in battle.

In a mid-credits scene, a crippled Harrow is abducted from a psychiatric hospital and executed by Jake Lockley, Spector and Grant's third alter who is still bonded with Khonshu.

[6] Slater and Diab executive produce alongside Marvel Studios' Kevin Feige, Louis D'Esposito, Victoria Alonso, Brad Winderbaum, and Grant Curtis and star Oscar Isaac.

[9] Diab's wife and producing partner Sarah Goher felt the scene of Layla El-Faouly saving a van and a younger girl in her hero attire would be a "magical moment for lots of people around the world" who would finally see themself represented in a superhero property and "feel like they belong".

[10] Diab noted El-Fouly's ending was kept open, believing this was the beginning of a new journey for her, saying continuing her partnership with Taweret would be "so interesting and they can drive each other crazy.

[11][12] Diab enjoyed the open nature by the end of the series regarding if the events of Moon Knight had taken place all within Spector's head, pointing out that there were many clues that clouded what was and was not real.

Slater noted that all of the creatives worked to find the proper balance of how many overt hints to leave regarding Lockley, deciding to focus on viewers unfamiliar with the character from the comics and creating a satisfying mystery for them.

[8] Diab revealed there had originally been a larger Marvel Cinematic Universe crossover in the credits scene, fitting with general convention that Marvel Studios' credits scenes help connect properties to the larger universe, which was removed to make it more a surprise that it did not connect back and help keep the series unique.

[12] The episode stars Oscar Isaac as Marc Spector / Moon Knight, Steven Grant / Mr. Knight, and Jake Lockley, May Calamawy as Layla El-Faouly / Scarlet Scarab, Khalid Abdalla as Selim, Ann Akinjirin as Bobbi, Antonia Salib as Taweret, Karim El-Hakim and F. Murray Abraham as the on-set performer and voice of Khonshu, respectively, Sofia Danu and Saba Mubarak as the on-set performer and voice of Ammit, respectively, and Ethan Hawke as Arthur Harrow.

Calamawy remembered from seeing Isaac's portrayal of Khonshu embodying Spector that it had to be a "weird sensation" adding, "Layla had just gone through so much so, I was like, what's a really intense way to show this happening?

[21] The episode featured a QR code that when scanned allowed viewers to access a free digital copy of Moon Knight Annual #1.

The site's critical consensus reads, "While Moon Knight's most interesting elements are somewhat eclipsed by a visual effects-laden showdown, "Gods and Monsters" brings this origin adventure to a satisfying close".

[31] Writing for Collider, Maggie Boccella gave the episode an "A+", calling Moon Knight the best MCU Disney+ series with "a short, but no less sweet" finale.

[34] For the 74th Primetime Creative Arts Emmy Awards, Meghan Kasperlik, Martin Mandeville, Richard Davies, and Wilberth Gonzalez were nominated for Outstanding Fantasy/Sci-Fi Costumes; Bonnie Wild, Mac Smith, Kimberly Patrick, Vanessa Lapato, Matt Hartman, Teresa Eckton, Tim Farrell, Leo Marcil, Joel Raabe, Ian Chase, Anele Onyekwere, Stephanie Lowry, Carl Sealove, Dan O'Connell, and John Cucci won for Outstanding Sound Editing for a Limited or Anthology Series, Movie or Special; Bonnie Wild, Scott R. Lewis, Tamás Csaba, and Scott Michael Smith were nominated for Outstanding Sound Mixing for a Limited or Anthology Series or Movie; and Daren Nop, Jamel Blissat, Estelle Darnault, and Sara Leal were nominated for Outstanding Stunt Performance.