Gonzalo de Mendoza (around 1510 in Baeza, Spain – 1558 in Asunción, Paraguay) was a Spanish conquistador and colonizer.
Under succeeding governors, he acted as their captain and lieutenant, while exploring Paraguay and Brazil.
During his term, the Ciudad Real del Guayrá was founded by Ruy Díaz de Malgarejo at the confluence of the Pepirí-Guazú and Paraná rivers.
This city received the settlers of Villa de Ontiveros [es] when it was abandoned and later grew large enough to briefly become the namesake for the governorate of Paraguay.
Mendoza was succeeded in his turn by captain Francisco Ortiz de Vergara in 1558.