Other notable singles include "Slide", "Black Balloon", and "Broadway" from Dizzy Up the Girl (1998); "Here Is Gone" from Gutterflower (2002); and "Better Days", "Give a Little Bit", and "Stay with You" from Let Love In (2006).

They played around Buffalo's underground music circuit and across the country opening for punk bands such as Gang Green, SNFU, Dag Nasty, Bad Religion, Motörhead, ALL, The Dead Milkmen, Doughboys, Big Drill Car, The Gun Club, Uniform Choice, The Dickies, and DRI and playing with fellow Buffalo bands.

[17] The band released its third album, Hold Me Up, in 1990 and featured Rzeznik as the lead vocalist on five tracks, including the single "There You Are"—as well as their then-concert favorite, "Two Days in February".

The critical success and encouraging sales of their last album resulted in a larger budget from Metal Blade Records.

The single "We Are the Normal", co-written with Paul Westerberg of The Replacements, Westerburg providing the lyrics, received a major push toward play on college and independent radio, and its video was displayed on MTV's 120 Minutes program.

[citation needed] Rzeznik was approached to write a song for the City of Angels soundtrack, and the end product was "Iris".

According to several interviews with Rzeznik, he was experiencing serious bouts of writer's block when he was approached, and was on the verge of quitting the band days before he wrote the song.

On July 4, 2004, the band performed a free concert in Buffalo, playing through a deluge of rain that can be seen on the DVD released later that year.

[citation needed] Though the album has not (as of 2007) been certified by the Recording Industry Association of America (RIAA), various music sites have asserted that it has gone gold.

[29] On November 13, 2007, the Goo Goo Dolls released a greatest hits album entitled Greatest Hits Volume One: The Singles, which includes a new version of "Name" recorded and mixed by Paul David Hager, and a remix of "Feel the Silence" by Michael Brauer.

[34][better source needed] While the album was full of the pop-rock that has sustained the band for decades, lead singer/guitarist Rzeznik's songwriting took on a more somber, serious tone.

[40] In November 2014, Malinin sued the band for wrongful termination, claiming that he was fired after requesting paternity leave.

[47] With 2018 marking the 20th anniversary of Dizzy Up the Girl, the band embarked on a commemorative tour where they performed the album in its entirety.

On record store day (April 13, 2019), a vinyl box limited to 1000 copies under the name Topography was released.

[25] In May 2021, the band announced that Rarities, a double compilation featuring rare and unheard songs spanning from 1995 to 2007, would be released on June 25, 2021.

[48] In a June 2021 interview published on YouTube, singer John Rzeznik revealed that the band was working on their 14th studio album, which would be released sometime in 2022.

Specifically, the band used earlier forms of production which they utilized prior to the digital era in the music industry.

He added that the album would sound more experimental than the band's past releases, hinting that he did not believe it would receive much radio airplay.

[52] On June 27, 2022, the band officially announced on their Facebook page the title of their new album, Chaos in Bloom, as well as the first single off it, "Yeah, I Like You".

At the 41st Grammy Awards, "Iris" received nominations for "Record of the Year" and "Pop Performance by a Duo or Group".