The hospital was historically affiliated with the Episcopal Church, but currently pastoral care services are available for all religions and denominations.

Presidential candidate United States senator Robert F. Kennedy died at the hospital early in the morning of June 6, 1968, 25 hours after he was shot at the Ambassador Hotel.

[4] In 1996, the hospital's neonatal intensive care unit was featured in Visiting... with Huell Howser Episode 401.

Chief Nurse Union Representative Alejandro Cuevas said that Good Samaritan Hospital has put patients at risk just to save money in the process.

Good Samaritan has also been accused of violating California's safe staffing law due to its chronic short-staffing, which has led to nurses assigned too many patients to care for and that means they are unable to take breaks during their 12-hour shifts, forcing them to work overtime and take extra shifts.