Ramana was born on 5 April1952 to Hanumantha Rao and Bala Tripurasundaramma in Kolakaluru village of Tenali, Guntur, Andhra Pradesh, India.
His first appearance was in the play Manavuni Adugujadallo, written by Avula Sambasiva Rao, during his high school.
In 2004, Ramana made his feature film debut in Grahanam, directed by Mohana Krishna Indraganti.
He got breakthrough for playing the role of Kondalrao in the film Middle Class Melodies (2020), which was premiered on Amazon Prime Video.
[5][6] He have later appeared in notable films like Ashoka Vanamlo Arjuna Kalyanam (2022), Bedurulanka 2012 (2023) and Ambajipeta Marriage Band (2024).