Finally, he served Toyotomi Hideyori and Yodo-dono and was killed at the battle of Dōmyōji during the siege of Osaka in 1615.

[3] During the Siege of Osaka, Gotō was one of the most able and fierce generals in Toyotomi Hideyori's Army.

He was the chief commander at the battle of Dōmyōji where, severely outnumbered by Date Masamune troops, he held out for reinforcements, which were lost in the fog.

After his death, Mototsugu's samurai were easily defeated and his head discovered by enemy forces.

History said that his display of valor this day was great enough to shock everyone, allies and enemies : leading his warriors in hit & run tactics, he killed 70 to 80 horse-men by himself.