[1][2] Huppertz studied at the Conservatory of Music in Cologne and worked during World War I in Coburg, where he debuted in 1910 as a singer and actor.
His first composition, "Rankende Rosen", was dedicated to the actor Rudolf Klein-Rogge, who introduced him in the early 1920s to director Fritz Lang and to Thea von Harbou (who later married Lang, but was at the time still married to Klein-Rogge).
In the film, Dr. Mabuse, der Spieler (1922), Huppertz worked as an extra in the role of a hotel manager.
The theme music for the first of the Karl May talkies, Across the Desert (1936), is included in the Karl May Film Music Collection Box Wild West, Hot Orient.
Huppertz died suddenly of a heart attack in 1937. Letters of Gottfried Huppertz are held by the Leipzig music publisher CF Peters in the Leipzig State Archives.