It extends over a length of around 650 m (2,132.5 ft) in an east–west direction from the Inner City Ring Road at the level of St. Thomas Church to the Poniatowski monument at Elstermühlgraben.

From 1901 to 1902, the originally privately run Centraltheater was built between Gottschedstrasse and Thomasring (today Dittrichring) on Bosestrasse, which was transferred to municipal ownership in 1912 as part of the Leipzig Theater.

[8] In the mid-1990s, the Maga Pon café with a Self-service laundry was opened in one of the numerous buildings in need of renovation at the time, and it quickly became very popular among Leipzig students and artists.

[9][10] Since the 2006 FIFA World Cup, Gottschedstrasse has been one of the city of Leipzig's fan miles for international football tournaments, so also in UEFA Euro 2024.

[11] To this day, some of the buildings on the street consist of representative revenue houses in closed developments, which were built from the end of the 19th century and offered space for small businesses on the lower floors .

[13] Immediately after the destruction, Hubert Ritter, the local city planning officer until 1930, submitted a project sketch for the new development of the site on behalf of the Leipzig Insurance Company on 23 December 1938, but it received no attention.

[16] The first Leipzig apartment of the Austrian composer, conductor and Kapellmeister Gustav Mahler (1860–1911), who worked in the city from 1886 to 1888, was on the second floor of what is now Gottschedstrasse 25 (then 4) from 1886 to the end of January 1887.

[17] Walter Ulbricht, who later became a politician and chairman of the Central Committee of the Socialist Unity Party of Germany and the State Council of the GDR, was born in the attic apartment in the same house in 1893 and spent the first seven years of his life there.