It is headed by the President of the Regional Government of Extremadura, a position currently held by María Guardiola of the People's Party.

[3] Its legislative branch is the unicameral Assembly of Extremadura.

Each minister is in charge of one Ministry and is freely appointed and dismissed by the President, reporting to the Assembly.

In accordance with the President's general guidelines, the government establishes policy and directs the administration of the Autonomous Region, exercising its executive and regulatory powers under the Spanish Constitution and the Statute of Extremadura.

Their headquarters are in Mérida, capital of Extremadura, in accordance with Article 5 of the Statute of Autonomy.