Its powers and structure are set out in the provisions of the 1973 Constitution, in which 30 Districts of 7 Divisions under its authority and jurisdiction.

The Chief Secretary of Sindh is usually a Grade 22 officer, belonging to the Pakistan Administrative Service.

The Chief Minister, invariably a leader of a political party represented in the Assembly, selects members of the provincial Cabinet.

Apart from the Ministerial level, the Government of Sindh exercises its powers and function through Divisions and Districts.

There are 6 Divisions, namely; Karachi, Hyderabad, Sukkur, Larkana, Mirpurkhas, and Shaheed Benazirbad.