She signed with Selig Polyscope Company in 1914, and made her film debut in the comedy short The Clock Went Wrong.

She appeared in Below the Surface (1920), starring with Hobart Bosworth and Lloyd Hughes,[12] and that same year played in A Dangerous Adventure, produced and directed by Warner Brothers.

[14] In the July edition of Motion Picture Magazine, she was featured in an article by Joan Tully entitled "Mantled With Shyness (A Word Portrait of Grace Darmond)".

When the advent of talkies came about, Darmond, like so many actresses and actors from the silent film era, was not able to make a successful transition.

[17] Although performing in a substantial number of films over roughly 13 years, she was known in Hollywood's inner circle as the lover of actress Jean Acker, the first wife of actor Rudolph Valentino.

Acker met relatively unknown actor Rudolph Valentino only a few months later at a party at Nazimova's home.

[21] Darmond evidently lied about her age to her fiancé, as well as the county clerk, as she would have been at least 29 at the time the marriage licence was issued.

[25] At the time, she was being treated for lung pain at the Motion Picture & Television Country Hospital in Woodland Hills, Los Angeles.